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An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase
The SCF ubiquitin ligases target proteins for degradation by recruitment factors called F-box proteins(1, 2). We identified a bi-planar dicarboxylic acid compound, called SCF-I2, as an inhibitor of substrate phosphodegron recognition by the yeast F-box protein Cdc4. SCF-I2 inhibits the binding and u...
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| Gepubliceerd in: | Nat Biotechnol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4445864/ https://ncbi.nlm.nih.gov/pubmed/20581844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1646 |
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