An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase

The SCF ubiquitin ligases target proteins for degradation by recruitment factors called F-box proteins(1, 2). We identified a bi-planar dicarboxylic acid compound, called SCF-I2, as an inhibitor of substrate phosphodegron recognition by the yeast F-box protein Cdc4. SCF-I2 inhibits the binding and u...

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: Orlicky, Stephen, Tang, Xiaojing, Neduva, Victor, Elowe, Nadine, Brown, Eric, Sicheri, Frank, Tyers, Mike
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445864/
https://ncbi.nlm.nih.gov/pubmed/20581844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1646
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