Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCF(Cdc4) ubiquitin ligase

The ubiquitin ligase SCF(Cdc4) (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sic1, in a multisite phosphorylation-dependent manner. Although short diphosphorylated peptides derived from Sic1 can bind to Cdc4 with high affinity, through systematic mutagenes...

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Main Authors: Tang, Xiaojing, Orlicky, Stephen, Mittag, Tanja, Csizmok, Veronika, Pawson, Tony, Forman-Kay, Julie D., Sicheri, Frank, Tyers, Mike
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295303/
https://ncbi.nlm.nih.gov/pubmed/22328159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116455109
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