A substrate binding model for the KEOPS tRNA modifying complex

The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms examined. In humans, pathogenic mutations in KEOPS genes lead to Galloway–Mowat syndrome, an autosomal-recessive dis...

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Опубликовано в: :Nat Commun
Главные авторы: Beenstock, Jonah, Ona, Samara Mishelle, Porat, Jennifer, Orlicky, Stephen, Wan, Leo C. K., Ceccarelli, Derek F., Maisonneuve, Pierre, Szilard, Rachel K., Yin, Zhe, Setiaputra, Dheva, Mao, Daniel Y. L., Khan, Morgan, Raval, Shaunak, Schriemer, David C., Bayfield, Mark A., Durocher, Daniel, Sicheri, Frank
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718258/
https://ncbi.nlm.nih.gov/pubmed/33277478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19990-5
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