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A Structure-based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-box Ubiquitin Ligases

Skp1-Cul1-F-box (SCF) E3 ligases constitute the largest and best characterized family of the multisubunit E3 ligases with important cellular functions and numerous disease links. The specificity of a SCF E3 ligase is established by one of the 69 human F-box proteins that are recruited to Cul1 throug...

詳細記述

保存先:
書誌詳細
出版年:Structure
主要な著者: Gorelik, Maryna, Manczyk, Noah, Pavlenco, Alia, Kurinov, Igor, Sidhu, Sachdev S., Sicheri, Frank
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415690/
https://ncbi.nlm.nih.gov/pubmed/30033217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.06.004
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