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A Structure-based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-box Ubiquitin Ligases
Skp1-Cul1-F-box (SCF) E3 ligases constitute the largest and best characterized family of the multisubunit E3 ligases with important cellular functions and numerous disease links. The specificity of a SCF E3 ligase is established by one of the 69 human F-box proteins that are recruited to Cul1 throug...
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| Izdano u: | Structure |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6415690/ https://ncbi.nlm.nih.gov/pubmed/30033217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.06.004 |
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