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Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants

The ubiquitin proteasome system (UPS) has garnered much attention due to its potential for the development of therapeutics. Following a successful clinical application of general proteasome inhibitors much effort has been devoted to targeting individual UPS components including E3 enzymes and deubiq...

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Detalhes bibliográficos
Publicado no:Bioeng Transl Med
Main Authors: Gorelik, Maryna, Sidhu, Sachdev S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434665/
https://ncbi.nlm.nih.gov/pubmed/28580429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10044
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