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Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants

The ubiquitin proteasome system (UPS) has garnered much attention due to its potential for the development of therapeutics. Following a successful clinical application of general proteasome inhibitors much effort has been devoted to targeting individual UPS components including E3 enzymes and deubiq...

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Vydáno v:Bioeng Transl Med
Hlavní autoři: Gorelik, Maryna, Sidhu, Sachdev S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434665/
https://ncbi.nlm.nih.gov/pubmed/28580429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10044
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