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Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases
[Image: see text] One effective means to achieve inhibitor specificity for RAF kinases, an important family of cancer drug targets, has been to target the monomeric inactive state conformation of the kinase domain, which, unlike most other kinases, can accommodate sulfonamide-containing drugs such a...
Zapisane w:
| Wydane w: | ACS Med Chem Lett |
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| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2019
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6627727/ https://ncbi.nlm.nih.gov/pubmed/31312411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00194 |
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