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Effects of rigidity on the selectivity of protein kinase inhibitors

Established strategies for discovering selective kinase inhibitors are target-centric as they often target certain structural or reactive features in the target kinase. In the absence of such prominent features, there is a lack of general methods for discovering selective inhibitors. Here we describ...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Assadieskandar, Amir, Yu, Caiqun, Maisonneuve, Pierre, Liu, Xu, Chen, Ying-Chu, Surya Prakash, G. K., Kurinov, Igor, Sicheri, Frank, Zhang, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816697/
https://ncbi.nlm.nih.gov/pubmed/29407977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.01.053
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