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A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases
Although a previously developed bump-hole approach has proven powerful in generating specific inhibitors for mapping functions of protein kinases, its application is limited by the intolerance of the large-to-small mutation by certain kinases and the inability to control two kinases separately in th...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7485388/ https://ncbi.nlm.nih.gov/pubmed/28459525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01083 |
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