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A chemoproteomic method for identifying cellular targets of covalent kinase inhibitors

Protein kinases are attractive drug targets for numerous human diseases including cancers, diabetes and neurodegeneration. A number of kinase inhibitors that covalently target a cysteine residue in their target kinases have recently entered use in the cancer clinic. Despite the advantages of covalen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes Cancer
Hauptverfasser: Chen, Ying-Chu, Zhang, Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979588/
https://ncbi.nlm.nih.gov/pubmed/27551330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.106
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