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A Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes

Small molecule inhibitors often only block a subset of the cellular functions of their protein targets. In many cases, how inhibiting only a portion of a multi-functional protein’s functions affects the state of the cell is not well understood. Therefore, tools that allow the systematic characteriza...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Fang, Linglan, Chakraborty, Sujata, Dieter, Emily M., Potter, Zachary E., Lombard, Chloe K., Maly, Dustin J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688853/
https://ncbi.nlm.nih.gov/pubmed/31274292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02963
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