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MEK drives BRAF activation through allosteric control of KSR proteins
RAF family kinases play prominent roles in cancer(1). Their activation is dependent on dimerization of their kinase domains, which has emerged as a roadblock for drug development(2,3). In mammals, RAF family kinases include three catalytically competent enzymes (A, B, and CRAF) and two pseudokinases...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433120/ https://ncbi.nlm.nih.gov/pubmed/29433126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25478 |
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