A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila

RAF is a critical effector of the small GTPase RAS in normal and malignant cells. Despite intense scrutiny, the mechanism regulating RAF activation remains partially understood. Here, we show that the scaffold KSR (kinase suppressor of RAS), a RAF homolog known to assemble RAF/MEK/ERK complexes, ind...

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Bibliografiske detaljer
Main Authors: Douziech, Mélanie, Sahmi, Malha, Laberge, Gino, Therrien, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472284/
https://ncbi.nlm.nih.gov/pubmed/16600912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1390406
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