Cargando...
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
First-generation RAF inhibitors paradoxically induce ERK signaling in normal and tumor cells exhibiting RAS activity. Compound-induced RAF dimerization through stabilization of the RAF ON/active state by inhibitors has emerged as a critical contributing factor. RAF inhibitors also enhance RAS−RAF as...
Guardado en:
| Publicado en: | Nat Commun |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5662619/ https://ncbi.nlm.nih.gov/pubmed/29084939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01274-0 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|