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RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
First-generation RAF inhibitors paradoxically induce ERK signaling in normal and tumor cells exhibiting RAS activity. Compound-induced RAF dimerization through stabilization of the RAF ON/active state by inhibitors has emerged as a critical contributing factor. RAF inhibitors also enhance RAS−RAF as...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5662619/ https://ncbi.nlm.nih.gov/pubmed/29084939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01274-0 |
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