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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

The Ras/Raf/MEK/ERK signal transduction pathway is a major regulator of cell proliferation activated by Ras-GTP. The oncogenic mutant RasQ61L is not able to hydrolyze GTP in the presence of Raf and thus is a constitutive activator of this mitogenic pathway. The Ras/Raf interaction is essential for t...

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Detalles Bibliográficos
Publicado en:Structure
Autores principales: Fetics, Susan K., Guterres, Hugo, Kearney, Bradley M., Buhrman, Greg, Ma, Buyong, Nussinov, Ruth, Mattos, Carla
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755167/
https://ncbi.nlm.nih.gov/pubmed/25684575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.12.017
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