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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
The Ras/Raf/MEK/ERK signal transduction pathway is a major regulator of cell proliferation activated by Ras-GTP. The oncogenic mutant RasQ61L is not able to hydrolyze GTP in the presence of Raf and thus is a constitutive activator of this mitogenic pathway. The Ras/Raf interaction is essential for t...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7755167/ https://ncbi.nlm.nih.gov/pubmed/25684575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.12.017 |
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