Cargando...
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
The Ras/Raf/MEK/ERK signal transduction pathway is a major regulator of cell proliferation activated by Ras-GTP. The oncogenic mutant RasQ61L is not able to hydrolyze GTP in the presence of Raf and thus is a constitutive activator of this mitogenic pathway. The Ras/Raf interaction is essential for t...
Guardado en:
| Publicado en: | Structure |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7755167/ https://ncbi.nlm.nih.gov/pubmed/25684575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.12.017 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|