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Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

Ras is a key signal transduction protein in the cell. Mutants of Gly(12) and Gln(61) impair GTPase activity and are found prominently in cancers. In wild type Ras-GTP, an allosteric switch promotes disorder to order transition in switch II, placing Gln(61) in the active site. We show that the “on” a...

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Bibliografiske detaljer
Main Authors: Buhrman, Greg, Kumar, V. S. Senthil, Cirit, Murat, Haugh, Jason M., Mattos, Carla
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030338/
https://ncbi.nlm.nih.gov/pubmed/21098031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193854
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