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Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase
Ras is a key signal transduction protein in the cell. Mutants of Gly(12) and Gln(61) impair GTPase activity and are found prominently in cancers. In wild type Ras-GTP, an allosteric switch promotes disorder to order transition in switch II, placing Gln(61) in the active site. We show that the “on” a...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3030338/ https://ncbi.nlm.nih.gov/pubmed/21098031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193854 |
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