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Does Ras Activate Raf and PI3K Allosterically?

The mechanism through which oncogenic Ras activates its effectors is vastly important to resolve. If allostery is at play, then targeting allosteric pathways could help in quelling activation of MAPK (Raf/MEK/ERK) and PI3K (PI3K/Akt/mTOR) cell proliferation pathways. On the face of it, allosteric ac...

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Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Nussinov, Ruth, Tsai, Chung-Jung, Jang, Hyunbum
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874141/
https://ncbi.nlm.nih.gov/pubmed/31799192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01231
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