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The Structural Basis for Ras Activation of PI3Kα Lipid Kinase

PI3Kα is a principal Ras effector that phosphorylates PIP(2) to PIP(3) in the PI3K/Akt/mTOR pathway. How Ras activates PI3K has been unclear: is Ras’ role confined to PI3K recruitment to the membrane or does Ras activation also involve allostery? Recently, we determined the mechanism of PI3Kα activa...

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Bibliografische gegevens
Gepubliceerd in:Phys Chem Chem Phys
Hoofdauteurs: Zhang, Mingzhen, Jang, Hyunbum, Nussinov, Ruth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556208/
https://ncbi.nlm.nih.gov/pubmed/31135801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cp00101h
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