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The Structural Basis for Ras Activation of PI3Kα Lipid Kinase
PI3Kα is a principal Ras effector that phosphorylates PIP(2) to PIP(3) in the PI3K/Akt/mTOR pathway. How Ras activates PI3K has been unclear: is Ras’ role confined to PI3K recruitment to the membrane or does Ras activation also involve allostery? Recently, we determined the mechanism of PI3Kα activa...
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| Publicado en: | Phys Chem Chem Phys |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556208/ https://ncbi.nlm.nih.gov/pubmed/31135801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cp00101h |
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