A carregar...
The mechanism of PI3Kα activation at the atomic level
PI3K lipid kinases phosphorylate PIP(2) to PIP(3) in the PI3K/Akt/mTOR pathway to regulate cellular processes. They are frequently mutated in cancer. Here we determine the PI3Kα activation mechanism at the atomic level. Unlike protein kinases where the substrate abuts the ATP, crystal structures ind...
Na minha lista:
| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430085/ https://ncbi.nlm.nih.gov/pubmed/30996962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc04498h |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|