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Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH(2) Domains
How calmodulin (CaM) acts in KRAS-driven cancers is a vastly important question. CaM binds to and stimulates PI3Kα/Akt signaling, promoting cell growth and proliferation. Phosphorylation of CaM at Tyr(99) (pY99) enhances PI3Kα activation. PI3Kα is a lipid kinase. It phosphorylates PIP(2) to produce...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5685777/ https://ncbi.nlm.nih.gov/pubmed/29117520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.09.008 |
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