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Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit
Calmodulin (CaM) is a calcium sensor protein that directly interacts with the dual-specificity (lipid and protein) kinase PI3Kα through the SH2 domains of the p85 regulatory subunit. In adenocarcinomas, the CaM interaction removes the autoinhibition of the p110 catalytic subunit of PI3Kα, leading to...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6454211/ https://ncbi.nlm.nih.gov/pubmed/29494137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01130 |
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