GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

K-Ras4B, a frequently mutated oncogene in cancer, plays an essential role in cell growth, differentiation, and survival. Its C-terminal membrane-associated hypervariable region (HVR) is required for full biological activity. In the active GTP-bound state, the HVR interacts with acidic plasma membran...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lu, Shaoyong, Banerjee, Avik, Jang, Hyunbum, Zhang, Jian, Gaponenko, Vadim, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661403/
https://ncbi.nlm.nih.gov/pubmed/26453300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664755
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