High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades. They contain highly homologous catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isoforms. KRAS is among the most fre...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Chavan, Tanmay S., Jang, Hyunbum, Khavrutskii, Lyuba, Abraham, Sherwin J., Banerjee, Avik, Freed, Benjamin C., Johannessen, Liv, Tarasov, Sergey G., Gaponenko, Vadim, Nussinov, Ruth, Tarasova, Nadya I.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699860/
https://ncbi.nlm.nih.gov/pubmed/26682817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.09.034
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