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Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region
K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogeni...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392252/ https://ncbi.nlm.nih.gov/pubmed/25713064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620724 |
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