Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogeni...

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Vydáno v:J Biol Chem
Hlavní autoři: Jang, Hyunbum, Abraham, Sherwin J., Chavan, Tanmay S., Hitchinson, Ben, Khavrutskii, Lyuba, Tarasova, Nadya I., Nussinov, Ruth, Gaponenko, Vadim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392252/
https://ncbi.nlm.nih.gov/pubmed/25713064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620724
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