GTP-Dependent K-Ras Dimerization

Ras proteins recruit and activate effectors, including Raf, that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, activation of Raf requires its dimerization. It has been suspected that dimeric Ras may promote dimerization and activation of Raf. Here we show that the GTP-bou...

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Publicado en:Structure
Autores principales: Muratcioglu, Serena, Chavan, Tanmay S., Freed, Benjamin C., Jang, Hyunbum, Khavrutskii, Lyuba, Freed, R. Natasha, Dyba, Marzena A., Stefanisko, Karen, Tarasov, Sergey G., Gursoy, Attila, Keskin, Ozlem, Tarasova, Nadya I., Gaponenko, Vadim, Nussinov, Ruth
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497850/
https://ncbi.nlm.nih.gov/pubmed/26051715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.04.019
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