GTP-Dependent K-Ras Dimerization

Ras proteins recruit and activate effectors, including Raf, that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, activation of Raf requires its dimerization. It has been suspected that dimeric Ras may promote dimerization and activation of Raf. Here we show that the GTP-bou...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Muratcioglu, Serena, Chavan, Tanmay S., Freed, Benjamin C., Jang, Hyunbum, Khavrutskii, Lyuba, Freed, R. Natasha, Dyba, Marzena A., Stefanisko, Karen, Tarasov, Sergey G., Gursoy, Attila, Keskin, Ozlem, Tarasova, Nadya I., Gaponenko, Vadim, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497850/
https://ncbi.nlm.nih.gov/pubmed/26051715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.04.019
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