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Inhibition of Nonfunctional Ras
Intuitively, functional states should be targeted; not nonfunctional ones. So why could drugging the inactive K-Ras4B(G12C) work – but, drugging the inactive kinase will likely not? The reason is the distinct oncogenic mechanisms. Kinase driver mutations work by stabilizing the active state and/or d...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897307/ https://ncbi.nlm.nih.gov/pubmed/33440168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.12.012 |
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