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PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization
To signal, Ras isoforms must be enriched at the plasma membrane (PM). It was suggested that phosphodiesterase-δ (PDEδ) can bind and shuttle some farnesylated Ras isoforms to the PM, but not all. Among these, interest focused on K-Ras4B, the most abundant oncogenic Ras isoform. To study PDEδ/Ras inte...
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| Publicado en: | J Phys Chem B |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7891760/ https://ncbi.nlm.nih.gov/pubmed/28540724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b03035 |
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