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The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding
The C-terminal hypervariable region (HVR) of the splice variant KRAS4B is disordered. Classically, the role of the post-translationally-modified HVR is to navigate Ras in the cell and to anchor it in localized plasma membrane regions. Here we propose additional regulatory roles, including auto-inhib...
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| Udgivet i: | Curr Opin Struct Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4785042/ https://ncbi.nlm.nih.gov/pubmed/26709496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2015.11.010 |
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