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The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

The C-terminal hypervariable region (HVR) of the splice variant KRAS4B is disordered. Classically, the role of the post-translationally-modified HVR is to navigate Ras in the cell and to anchor it in localized plasma membrane regions. Here we propose additional regulatory roles, including auto-inhib...

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Bibliografski detalji
Izdano u:Curr Opin Struct Biol
Glavni autori: Banerjee, Avik, Jang, Hyunbum, Nussinov, Ruth, Gaponenko, Vadim
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785042/
https://ncbi.nlm.nih.gov/pubmed/26709496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2015.11.010
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