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The higher level of complexity of K-Ras4B activation at the membrane
Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5′-diphosphate...
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| 出版年: | FASEB J |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Federation of American Societies for Experimental Biology
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4799498/ https://ncbi.nlm.nih.gov/pubmed/26718888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-279091 |
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