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The higher level of complexity of K-Ras4B activation at the membrane

Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5′-diphosphate...

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Bibliografiska uppgifter
I publikationen:FASEB J
Huvudupphovsmän: Jang, Hyunbum, Banerjee, Avik, Chavan, Tanmay S., Lu, Shaoyong, Zhang, Jian, Gaponenko, Vadim, Nussinov, Ruth
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799498/
https://ncbi.nlm.nih.gov/pubmed/26718888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-279091
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