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The higher level of complexity of K-Ras4B activation at the membrane
Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5′-diphosphate...
Enregistré dans:
| Publié dans: | FASEB J |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Federation of American Societies for Experimental Biology
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4799498/ https://ncbi.nlm.nih.gov/pubmed/26718888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-279091 |
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