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Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition
PI3K and PTEN are the second and third most highly mutated proteins in cancer following only p53. Their actions oppose each other. PI3K phosphorylates signaling lipid PIP(2) to PIP(3). PTEN dephosphorylates it back. Driver mutations in both proteins accrue PIP(3). PIP(3) recruits Akt and PDK1 to the...
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| Publicat a: | Mol Cancer Res |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026595/ https://ncbi.nlm.nih.gov/pubmed/33288731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0818 |
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