Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

Autoinhibition is an effective mechanism that guards proteins against spurious activation. Despite its ubiquity, the distinct organizations of the autoinhibited states and their release mechanisms differ. Signaling is most responsive to the cell environment only if a small shift in the equilibrium i...

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Bibliografiske detaljer
Udgivet i:Biophys Rev
Main Authors: Nussinov, Ruth, Zhang, Mingzhen, Tsai, Chung-Jung, Liao, Tsung-Jen, Fushman, David, Jang, Hyunbum
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233353/
https://ncbi.nlm.nih.gov/pubmed/30269291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-018-0461-0
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