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Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles
Membrane-anchored Ras family proteins are activated by guanine nucleotide exchange factors such as SOS1. The CDC25 domain of SOS1 catalyzes GDP-to-GTP exchange, thereby activating Ras. Here, we aim to decipher the activation mechanism of KRas4B, a significantly mutated oncogene. We perform large-sca...
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| Publicado en: | Biophys J |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6103739/ https://ncbi.nlm.nih.gov/pubmed/30097175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.07.016 |
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