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Comparison of the Conformations of KRAS Isoforms, K‑Ras4A and K‑Ras4B, Points to Similarities and Significant Differences

Human HRAS, KRAS, and NRAS genes encode four isoforms of Ras, a p21 GTPase. Mutations in KRAS account for the majority of RAS-driven cancers. The KRAS has two splice variants, K-Ras4A and K-Ras4B. Due to their reversible palmitoylation, K-Ras4A and N-Ras have bimodal signaling states. K-Ras4A and K-...

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Pubblicato in:J Phys Chem B
Autori principali: Chakrabarti, Mayukh, Jang, Hyunbum, Nussinov, Ruth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815164/
https://ncbi.nlm.nih.gov/pubmed/26761128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b11110
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