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Comparison of the Conformations of KRAS Isoforms, K‑Ras4A and K‑Ras4B, Points to Similarities and Significant Differences
Human HRAS, KRAS, and NRAS genes encode four isoforms of Ras, a p21 GTPase. Mutations in KRAS account for the majority of RAS-driven cancers. The KRAS has two splice variants, K-Ras4A and K-Ras4B. Due to their reversible palmitoylation, K-Ras4A and N-Ras have bimodal signaling states. K-Ras4A and K-...
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| Veröffentlicht in: | J Phys Chem B |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7815164/ https://ncbi.nlm.nih.gov/pubmed/26761128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b11110 |
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