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Oncogenic Ras Isoforms Signaling Specificity at the Membrane

How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas, HRas and NRas (K-Ras, H-Ras, N-Ras) differentially populate distinct cancers. How they selectively activate effectors and why is KRas4B the most prevalent are highly significant questions. Here we consider determinants...

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Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: Nussinov, Ruth, Tsai, Chung-Jung, Jang, Hyunbum
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811325/
https://ncbi.nlm.nih.gov/pubmed/29273632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2727
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