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A New View of Ras Isoforms in Cancers

Does small GTPase K-Ras4A have a single state or two states, one resembling K-Ras4B and the other N-Ras? A recent study of K-Ras4A made the remarkable observation that even in the absence of the palmitoyl K-Ras4A can be active at the plasma membrane. Importantly, this suggests that K-Ras4A may exist...

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Detalles Bibliográficos
Publicado en:Cancer Res
Main Authors: Nussinov, Ruth, Tsai, Chung-Jung, Chakrabarti, Mayukh, Jang, Hyunbum
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644351/
https://ncbi.nlm.nih.gov/pubmed/26659836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1536
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