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A New View of Ras Isoforms in Cancers

Does small GTPase K-Ras4A have a single state or two states, one resembling K-Ras4B and the other N-Ras? A recent study of K-Ras4A made the remarkable observation that even in the absence of the palmitoyl K-Ras4A can be active at the plasma membrane. Importantly, this suggests that K-Ras4A may exist...

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發表在:Cancer Res
Main Authors: Nussinov, Ruth, Tsai, Chung-Jung, Chakrabarti, Mayukh, Jang, Hyunbum
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644351/
https://ncbi.nlm.nih.gov/pubmed/26659836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1536
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