Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

K-Ras is one of the most frequently mutated oncogenes in human tumor cells. It consists of a well-conserved globular catalytic domain and a flexible tail-like hypervariable region (HVR) at its C-terminal end. It plays a key role in signaling networks in proliferation, differentiation, and survival,...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Dudas, Balint, Merzel, Franci, Jang, Hyunbum, Nussinov, Ruth, Perahia, David, Balog, Erika
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366858/
https://ncbi.nlm.nih.gov/pubmed/32754617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00145
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