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Revealing the activation mechanism of autoinhibited RalF by integrated simulation and experimental approaches
RalF is an Arf GEF from Legionella pneumophilia, the bacterium that causes severe pneumonia. In its crystal structure, RalF is in the autoinhibited form. A large-scale domain motion is expected to lift the autoinhibition, the mechanism of which is still unknown. Since RalF is activated in the presen...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8115643/ https://ncbi.nlm.nih.gov/pubmed/33980916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89169-5 |
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