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SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations
Grb2 is an adaptor protein connecting the epidermal growth factor receptor and the downstream Son of sevenless 1 (SOS1), a Ras-specific guanine nucleotide exchange factor (RasGEF), which exchanges GDP by GTP. Grb2 contains three SH domains: N-terminal SH3 (nSH3), SH2, and C-terminal SH3 (cSH3). The...
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| Publicat a: | J Chem Phys |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
AIP Publishing LLC
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7390601/ https://ncbi.nlm.nih.gov/pubmed/32752665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/5.0013926 |
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