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The dynamic mechanism of RASSF5 and MST kinase activation by Ras
As a tumor suppressor, RASSF5 (NORE1A) activates MST1/2 thereby modulating the Hippo pathway. Structurally, activation involves RASSF5 and MST1/2 swapping their SARAH domains to form a SARAH heterodimer. This exposes the MST1/2 kinase domain which homodimerizes, leading to trans-autophosphorylation....
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| Publié dans: | Phys Chem Chem Phys |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381522/ https://ncbi.nlm.nih.gov/pubmed/28197608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cp08596b |
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