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Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

Autoinhibition is an effective mechanism that guards proteins against spurious activation. Despite its ubiquity, the distinct organizations of the autoinhibited states and their release mechanisms differ. Signaling is most responsive to the cell environment only if a small shift in the equilibrium i...

詳細記述

保存先:
書誌詳細
出版年:Biophys Rev
主要な著者: Nussinov, Ruth, Zhang, Mingzhen, Tsai, Chung-Jung, Liao, Tsung-Jen, Fushman, David, Jang, Hyunbum
フォーマット: Artigo
言語:Inglês
出版事項: Springer Berlin Heidelberg 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233353/
https://ncbi.nlm.nih.gov/pubmed/30269291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-018-0461-0
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