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PI3K inhibitors: review and new strategies
The search is on for effective specific inhibitors for PI3Kα mutants. PI3Kα, a critical lipid kinase, has two subunits, catalytic and inhibitory. PIK3CA, the gene that encodes the p110α catalytic subunit is a highly mutated protein in cancer. Dysregulation of PI3Kα signalling is commonly associated...
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| 發表在: | Chem Sci |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Royal Society of Chemistry
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7472334/ https://ncbi.nlm.nih.gov/pubmed/32953006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01676d |
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