Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers and, to a lesser extent, in solution as observed by size exclusion chromatography and confirmed by SAXS. Com...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Packer, Morgan R., Parker, Jillian A., Chung, Jean K., Li, Zhenlu, Lee, Young Kwang, Cookis, Trinity, Guterres, Hugo, Alvarez, Steven, Hossain, Md Amin, Donnelly, Daniel P., Agar, Jeffrey N., Makowski, Lee, Buck, Matthias, Groves, Jay T., Mattos, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958358/
https://ncbi.nlm.nih.gov/pubmed/33653954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015648118
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