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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers
Although RAF kinases are critical for controlling cell growth, their mechanism of activation is incompletely understood. Recently, dimerization was shown to be important for activation. Here we show that the dimer is functionally asymmetric with one kinase functioning as an activator to stimulate ac...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844432/ https://ncbi.nlm.nih.gov/pubmed/23993095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.046 |
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