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Critical Review Evolution of a Dynamic Molecular Switch

Eukaryotic protein kinases (EPKs) regulate almost every biological process and have evolved to be dynamic molecular switches; this is in stark contrast to metabolic enzymes, which have evolved to be efficient catalysts. In particular, the highly conserved active site of every EPK is dynamically and...

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Bibliographic Details
Published in:IUBMB Life
Main Authors: Taylor, Susan S., Meharena, Hiruy S., Kornev, Alexandr P.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690480/
https://ncbi.nlm.nih.gov/pubmed/31059206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.2059
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