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Dynamics driven allostery in protein kinases

Protein kinases have very dynamic structures and their functionality strongly depends on their dynamic state. Active kinases reveal a dynamic pattern with residues clustering into semirigid communities that move in µs-ms timescale. Previously detected hydrophobic spines serve as connectors between c...

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Veröffentlicht in:Trends Biochem Sci
Hauptverfasser: Kornev, Alexandr P., Taylor, Susan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630092/
https://ncbi.nlm.nih.gov/pubmed/26481499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2015.09.002
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