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Dynamic allostery-based molecular workings of kinase:peptide complexes

A dense interplay between structure and dynamics underlies the working of proteins, especially enzymes. Protein kinases are molecular switches that are optimized for their regulation rather than catalytic turnover rates. Using long-simulations dynamic allostery analysis, this study describes an expl...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ahuja, Lalima G., Aoto, Phillip C., Kornev, Alexandr P., Veglia, Gianluigi, Taylor, Susan S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660753/
https://ncbi.nlm.nih.gov/pubmed/31285328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900163116
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