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Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer
The expertise of protein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by their phosphotransferase activity. Only a few hundreds of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in health and disease. Th...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5307475/ https://ncbi.nlm.nih.gov/pubmed/28115705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620667114 |
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