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Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer
The expertise of protein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by their phosphotransferase activity. Only a few hundreds of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in health and disease. Th...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5307475/ https://ncbi.nlm.nih.gov/pubmed/28115705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620667114 |
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