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A dynamic hydrophobic core orchestrates allostery in protein kinases
Eukaryotic protein kinases (EPKs) constitute a class of allosteric switches that mediate a myriad of signaling events. It has been postulated that EPKs’ active and inactive states depend on the structural architecture of their hydrophobic cores, organized around two highly conserved spines: C-spine...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5384802/ https://ncbi.nlm.nih.gov/pubmed/28435869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600663 |
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