A dynamic hydrophobic core orchestrates allostery in protein kinases

Eukaryotic protein kinases (EPKs) constitute a class of allosteric switches that mediate a myriad of signaling events. It has been postulated that EPKs’ active and inactive states depend on the structural architecture of their hydrophobic cores, organized around two highly conserved spines: C-spine...

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Pubblicato in:Sci Adv
Autori principali: Kim, Jonggul, Ahuja, Lalima G., Chao, Fa-An, Xia, Youlin, McClendon, Christopher L., Kornev, Alexandr P., Taylor, Susan S., Veglia, Gianluigi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384802/
https://ncbi.nlm.nih.gov/pubmed/28435869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600663
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